Enzymatic transglycosylation of PEG brushes by β-galactosidase

Yan Fang; Wei Xu; Jian Wu; Zhi-Kang Xu

doi:10.1039/C2CC35369E

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Chemical Communications

Issue 91, 2012

Urgent high quality communications from across the chemical sciences.

Impact Factor 6.169 100 Issues per Year Indexed in MEDLINE

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Enzymatic transglycosylation of PEG brushes by β-galactosidase

Yan Fang,^a Wei Xu,^b Jian Wu^b and Zhi-Kang Xu*^a

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MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: xuzk@zju.edu.cn

Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Chem. Commun., 2012,48, 11208-11210

DOI: 10.1039/C2CC35369E
Received 25 Jul 2012, Accepted 27 Sep 2012
First published online 28 Sep 2012

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Enzymatic transglycosylation has been successfully implemented by β-galactosidase (β-Gal) on PEG brushes. Kinetic parameters validate this kind of chemoenzymatic strategy which is promising for construction of biomimetic surfaces with glycocalyx-like structures.

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