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Issue 80, 2012
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A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

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Abstract

We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.

Graphical abstract: A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

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Publication details

The article was received on 23 Jul 2012, accepted on 10 Aug 2012 and first published on 10 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35310E
Citation: Chem. Commun., 2012,48, 10007-10009
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    A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

    G. E. Mulder, J. A. W. Kruijtzer and R. M. J. Liskamp, Chem. Commun., 2012, 48, 10007
    DOI: 10.1039/C2CC35310E

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