A novel and easy practical direct synthesis of α-ketoamides has been developed without metals in water. This procedure was catalyzed by nBu4NI using TBHP as oxidant from simple substrates, aryl methyl ketones and dialkylformamides.
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nBu4NI-catalyzed direct synthesis of α-ketoamides from aryl methyl ketones with dialkylformamides in water using TBHP as oxidant
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School of Chemistry and Chemical Engineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, P. R. China
E-mail: maiwp@yahoo.com ;
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E-mail: maiwp@yahoo.com ;
Fax: +86-371-67756715 ;
Tel: +86-371-67756718
Chem. Commun., 2012,48, 10117-10119
DOI: 10.1039/C2CC35279F
Received 22 Jul 2012, Accepted 22 Aug 2012
First published online 23 Aug 2012
Chemical Communications
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