Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

Davinder Kumar; César A. Masitas; Tho N. Nguyen; Craig A. Grapperhaus

doi:10.1039/C2CC35256G

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Chemical Communications

Issue 3, 2013

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Bioinspired catalytic nitrile hydration by dithiolato, sulfinato/thiolato, and sulfenato/sulfinato ruthenium complexes

Davinder Kumar,^a César A. Masitas,^a Tho N. Nguyen^a and Craig A. Grapperhaus*^a

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Department of Chemistry, University of Louisville, Louisville, USA
E-mail: grapperhaus@louisville.edu ;
Fax: +1 502 852-8149 ;
Tel: +1 502 852-5932

Chem. Commun., 2013,49, 294-296

DOI: 10.1039/C2CC35256G
Received 20 Jul 2012, Accepted 14 Nov 2012
First published online 16 Nov 2012

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Abstract
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A series of Ru(II) catalysts inspired by the metalloenzyme nitrile hydratase catalyze the hydration of benzonitrile with up to 242 turnovers under neutral conditions with very low catalysts loading. Catalysts with an oxidized sulfur environment are less susceptible to product inhibition increasing the catalytic efficiency at low nitrile:water ratios.