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Issue 85, 2012
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A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

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Abstract

Lys16 is present in the core region of the amyloid β (Aβ) self-assembly in Alzheimer's disease. Here we report that the P9-NCS peptide can covalently react with Lys16 and inhibit Aβ neurotoxic fibrillization. Moreover P9-NCS has high selectivity and it cannot react with amylin, insulin, fetal bovine serum, Q11 and MUC1 peptide.

Graphical abstract: A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

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Publication details

The article was received on 19 Jul 2012, accepted on 02 Sep 2012 and first published on 03 Sep 2012


Article type: Communication
DOI: 10.1039/C2CC35178A
Citation: Chem. Commun., 2012,48, 10565-10567
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    A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

    J. Ma, L. Zhao, D. Zhao, Q. Liu, C. Liu, W. Wu, Y. Chen, Y. Zhao and Y. Li, Chem. Commun., 2012, 48, 10565
    DOI: 10.1039/C2CC35178A

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