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Issue 77, 2012
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Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding

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Abstract

Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.

Graphical abstract: Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding

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Publication details

The article was received on 18 Jul 2012, accepted on 05 Aug 2012 and first published on 06 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35166H
Citation: Chem. Commun., 2012,48, 9577-9579
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    Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding

    M. Samiappan, S. Alasibi, R. Cohen-Luria, A. Shanzer and G. Ashkenasy, Chem. Commun., 2012, 48, 9577
    DOI: 10.1039/C2CC35166H

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