Jump to main content
Jump to site search

Issue 79, 2012
Previous Article Next Article

Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril

Author affiliations

Abstract

Temozolomide (TMZ) is the primary chemotherapeutic agent for treatment of glioblastoma multiforme (GBM) yet it has a fast rate of degradation under physiological conditions to the ‘active’ MTIC, which has poor penetration of the blood–brain barrier and cellular absorption. Herein we have demonstrated binding of TMZ within the cavity of nano-container cucurbit[7]uril, resulting in a decreased rate of drug degradation. Prolonging the lifetime of the TMZ under physiological conditions through encapsulation dramatically improved the drug's activity against primary GBM cell lines as more TMZ could be absorbed by the cells before degradation. This work can potentially lead to increases in the drug's propensity for crossing the blood–brain barrier and absorption into the GBM cells, thereby increasing the efficacy of this chemotherapy.

Graphical abstract: Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 17 Jul 2012, accepted on 15 Aug 2012 and first published on 30 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35131E
Citation: Chem. Commun., 2012,48, 9843-9845
  •   Request permissions

    Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril

    E. A. Appel, M. J. Rowland, X. J. Loh, R. M. Heywood, C. Watts and O. A. Scherman, Chem. Commun., 2012, 48, 9843
    DOI: 10.1039/C2CC35131E

Search articles by author