Jump to main content
Jump to site search

Issue 82, 2012
Previous Article Next Article

Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

Author affiliations

Abstract

Coupling gold nanoparticle-based ligation to a ligation chain reaction enables colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity. One mutant in 2000 copies of a wild-type gene can be detected in 20–100 pg of PCR-amplified genomic DNA samples.

Graphical abstract: Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 13 Jun 2012, accepted on 28 Aug 2012 and first published on 29 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35070J
Citation: Chem. Commun., 2012,48, 10225-10227
  •   Request permissions

    Colorimetric detection of single-nucleotide polymorphisms with a real-time PCR-like sensitivity

    W. Shen, H. Deng, A. K. L. Teo and Z. Gao, Chem. Commun., 2012, 48, 10225
    DOI: 10.1039/C2CC35070J

Search articles by author