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Issue 85, 2012
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Nucleic acid aptamers: an emerging frontier in cancer therapy

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Abstract

The last two decades have witnessed the development and application of nucleic acid aptamers in a variety of fields, including target analysis, disease therapy, and molecular and cellular engineering. The efficient and widely applicable aptamer selection, reproducible chemical synthesis and modification, generally impressive target binding selectivity and affinity, relatively rapid tissue penetration, low immunogenicity, and rapid systemic clearance make aptamers ideal recognition elements for use as therapeutics or for in vivo delivery of therapeutics. In this feature article, we discuss the development and biomedical application of nucleic acid aptamers, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.

Graphical abstract: Nucleic acid aptamers: an emerging frontier in cancer therapy

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Publication details

The article was received on 13 Jul 2012, accepted on 21 Aug 2012 and first published on 21 Aug 2012


Article type: Feature Article
DOI: 10.1039/C2CC35042D
Citation: Chem. Commun., 2012,48, 10472-10480
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    Nucleic acid aptamers: an emerging frontier in cancer therapy

    G. Zhu, M. Ye, M. J. Donovan, E. Song, Z. Zhao and W. Tan, Chem. Commun., 2012, 48, 10472
    DOI: 10.1039/C2CC35042D

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