Intracellular self-assembly of nanoparticles for enhancing cell uptake

Qingqing Miao; Xiaoyu Bai; Yingying Shen; Bin Mei; Jinhao Gao; Li Li; Gaolin Liang

doi:10.1039/C2CC34899C

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Chemical Communications

Issue 78, 2012

Urgent high quality communications from across the chemical sciences.

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Intracellular self-assembly of nanoparticles for enhancing cell uptake

Qingqing Miao,^a Xiaoyu Bai,^a Yingying Shen,^b Bin Mei,^a Jinhao Gao,^c Li Li^b and Gaolin Liang*^a^c

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CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, P. R. China
E-mail: gliang@ustc.edu.cn ;
Fax: +86-551-3600730 ;
Tel: +86-551-3607935

State Key Laboratory of Oncology in Southern China, Imaging Diagnostic and Interventional Center, Cancer Center, Sun Yet-sen University, 651 Dongfeng Road East, Guangzhou, 510060, P. R. China

The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, 361005, P. R. China

Chem. Commun., 2012,48, 9738-9740

DOI: 10.1039/C2CC34899C
Received 09 Jul 2012, Accepted 17 Aug 2012
First published online 20 Aug 2012

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A radioactive probe (1) has been developed and applied to a condensation reaction and self-assembly of radioactive nanoparticles (i.e., ¹²⁵I-NPs) intracellularly. Upon 160 min cellular efflux, the radioactivity retained in cells incubated with 1 was 4-fold more higher than that of those cells treated with a scrambled control probe (1-Scr).

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Qingqing Miao
Xiaoyu Bai
Yingying Shen
Bin Mei
Jinhao Gao
Li Li
Gaolin Liang

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