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Issue 75, 2012
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Specific detection of DNA through coupling of a TaqMan assay with surface enhanced Raman scattering (SERS)

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Abstract

We have combined the benefits of a TaqMan assay with surface enhanced Raman scattering (SERS), to generate a novel DNA detection method which provides increased sensitivity, with clear applications for disease identification through clinical testing. Target DNA detection limits by SERS were shown to be lower than conventional fluorescence detection and clinically relevant samples of methicillin-resistant Staphylococcus aureus were detected with high specificity.

Graphical abstract: Specific detection of DNA through coupling of a TaqMan assay with surface enhanced Raman scattering (SERS)

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Publication details

The article was received on 07 Jul 2012, accepted on 01 Aug 2012 and first published on 14 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34859D
Citation: Chem. Commun., 2012,48, 9412-9414
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    Specific detection of DNA through coupling of a TaqMan assay with surface enhanced Raman scattering (SERS)

    M. M. Harper, B. Robertson, A. Ricketts and K. Faulds, Chem. Commun., 2012, 48, 9412
    DOI: 10.1039/C2CC34859D

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