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Issue 74, 2012
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Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as an effective additive

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Abstract

Cu-catalyzed cross-coupling of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as a ligand precursor was developed. The use of 1,3-butadiene resulted in improved yields of alkylalkyl products with improved selectivities.

Graphical abstract: Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as an effective additive

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Publication details

The article was received on 07 Jul 2012, accepted on 25 Jul 2012 and first published on 13 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34847K
Citation: Chem. Commun., 2012,48, 9313-9315
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    Copper-catalyzed coupling reaction of unactivated secondary alkyl iodides with alkyl Grignard reagents in the presence of 1,3-butadiene as an effective additive

    R. Shen, T. Iwasaki, J. Terao and N. Kambe, Chem. Commun., 2012, 48, 9313
    DOI: 10.1039/C2CC34847K

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