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Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
; Fax: +45 3533 6041
; Tel: +45 3533 6487
Chem. Commun., 2012,48, 9092-9094
02 Jul 2012,
20 Jul 2012
First published online
23 Jul 2012
A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2′-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.