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Issue 80, 2012
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Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

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Abstract

The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.

Graphical abstract: Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

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Publication details

The article was received on 30 Jun 2012, accepted on 17 Aug 2012 and first published on 22 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34684B
Citation: Chem. Commun., 2012,48, 10013-10015
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    Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

    A. Hamberg, S. Maurer and K. Hult, Chem. Commun., 2012, 48, 10013
    DOI: 10.1039/C2CC34684B

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