A two-step modular synthesis of an α-hydroxycyclopentenone and α-amido-indanones has been developed based on the Nazarov cyclization of 2-amido-1,4-pentadien-3-ones, readily accessed via formal hydroacylation of allenamides.
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Construction of α-amido-indanones via formal allenamide hydroacylation–Nazarov cyclization
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Department of Chemistry, University of Alberta, E3-43 Gunning/Lemieux Chemistry Centre, Edmonton, Canada
E-mail: frederick.west@ualberta.ca ;
Fax: +1 780-492-8231 ;
Tel: +1 780-492-8187
E-mail: frederick.west@ualberta.ca ;
Fax: +1 780-492-8231 ;
Tel: +1 780-492-8187
Chem. Commun., 2012,48, 9186-9188
DOI: 10.1039/C2CC34644C
Received 28 Jun 2012, Accepted 20 Jul 2012
First published online 23 Jul 2012
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