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Issue 78, 2012
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Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

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Abstract

A cytidine 5′-monophosphate (CMP)-sialic acid analogue carrying a fluorescent reporter group, an inhibitor of sialyltransferase, was synthesised in order to investigate glycan synthesis events in cells. The compound was found to be a substrate of a CMP-sialic acid transporter, and specific Golgi vesicles were visualised in the cells.

Graphical abstract: Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

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Publication details

The article was received on 27 Jun 2012, accepted on 13 Aug 2012 and first published on 14 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34605B
Citation: Chem. Commun., 2012,48, 9744-9746
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    Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

    K. Suzuki, A. Ohtake, Y. Ito and O. Kanie, Chem. Commun., 2012, 48, 9744
    DOI: 10.1039/C2CC34605B

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