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State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
; Fax: +86 731-88822782
; Tel: +86 731-88822577
Chem. Commun., 2012,48, 8820-8822
25 Jun 2012,
16 Jul 2012
First published online
17 Jul 2012
Based on a target-activated autocatalytic DNAzyme amplification strategy, novel fluorescence sensing platforms were constructed for highly sensitive and selective assay of base excision repair enzyme activity. By using a rolling circle amplification (RCA)-coupled amplification cascade, an extremely low detection limit (0.002 U mL−1) was achieved.
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