A simple and fast electrochemical nucleic acid assay based on a target recycling strategy and the release of a double-stranded DNA intercalating redox probe upon digestion of a specific duplex by exonuclease III is demonstrated.
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Homogeneous electrochemical monitoring of exonuclease III activity and its application to nucleic acid testing by target recycling
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Laboratoire d'Electrochimie Moléculaire, UMR 7591 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Jean-Antoine de Baïf, F-75205 Paris Cedex 13, France
E-mail: francois.mavre@univ-paris-diderot.fr ;
Fax: +33 157278788 ;
Tel: +33 157278789
E-mail: francois.mavre@univ-paris-diderot.fr ;
Fax: +33 157278788 ;
Tel: +33 157278789
Chem. Commun., 2012,48, 8772-8774
DOI: 10.1039/C2CC34511K
Received 23 Jun 2012, Accepted 04 Jul 2012
First published online 05 Jul 2012
Chemical Communications
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