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Issue 80, 2012
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A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

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Abstract

Fluorogenic sulforhodamine–neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250–400 fold enhancement in binding affinity relative to corresponding unconjugated fluorophores.

Graphical abstract: A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

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Publication details

The article was received on 22 Jun 2012, accepted on 23 Aug 2012 and first published on 24 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34498J
Citation: Chem. Commun., 2012,48, 10034-10036
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    A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

    J. Jeon, K. H. Lee and J. Rao, Chem. Commun., 2012, 48, 10034
    DOI: 10.1039/C2CC34498J

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