Issue 80, 2012

A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

Abstract

Fluorogenic sulforhodamine–neomycin conjugates have been designed and synthesized for RNA tagging. Conjugates were fluorescently activated by binding to RNA aptamers and exhibited greater than 250–400 fold enhancement in binding affinity relative to corresponding unconjugated fluorophores.

Graphical abstract: A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2012
Accepted
23 Aug 2012
First published
24 Aug 2012

Chem. Commun., 2012,48, 10034-10036

A strategy to enhance the binding affinity of fluorophore–aptamer pairs for RNA tagging with neomycin conjugation

J. Jeon, K. H. Lee and J. Rao, Chem. Commun., 2012, 48, 10034 DOI: 10.1039/C2CC34498J

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