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Issue 73, 2012
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Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

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Abstract

A diamine-catalyzed asymmetric tandem reaction between α,β-unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20 : 1 dr). The products obtained contain two pharmaceutically relevant features: the biologically active rhodanine moiety embedded in a spirocyclic unit.

Graphical abstract: Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

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Publication details

The article was received on 16 Jun 2012, accepted on 23 Jul 2012 and first published on 06 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34321E
Citation: Chem. Commun., 2012,48, 9180-9182
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    Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

    W. Wu, H. Huang, X. Yuan, K. Zhu and J. Ye, Chem. Commun., 2012, 48, 9180
    DOI: 10.1039/C2CC34321E

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