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Issue 90, 2012
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Asymmetric catalysis based on tropos ligands

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Abstract

All enantiopure atropisomeric (atropos) ligands essentially require enantiomeric resolution or synthetic transformation from a chiral pool. In sharp contrast, the use of tropos (chirally flexible) ligands, which are highly modular, versatile, and easy to synthesize without enantiomeric resolution, has recently been the topic of much interest in asymmetric catalysis. Racemic catalysts bearing tropos ligands can be applied to asymmetric catalysis through enantiomeric discrimination by the addition of a chiral source, which preferentially transforms one catalyst enantiomer into a highly activated catalyst enantiomer. Additionally, racemic catalysts bearing tropos ligands can also be utilized as atropos enantiopure catalysts obtained via the control of chirality by a chiral source followed by the memory of chirality. In this feature article, our results on the asymmetric catalysis via the combination of various central metals and tropos ligands are summarized.

Graphical abstract: Asymmetric catalysis based on tropos ligands

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Publication details

The article was received on 16 Jun 2012, accepted on 27 Jul 2012 and first published on 27 Jul 2012


Article type: Feature Article
DOI: 10.1039/C2CC34320G
Citation: Chem. Commun., 2012,48, 11050-11069
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    Asymmetric catalysis based on tropos ligands

    K. Aikawa and K. Mikami, Chem. Commun., 2012, 48, 11050
    DOI: 10.1039/C2CC34320G

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