A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers

Mengjie Chen; Chusen Huang; Chunsheng He; Weiping Zhu; Yufang Xu; Yunfeng Lu

doi:10.1039/C2CC34290A

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Chemical Communications

Issue 76, 2012

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A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers

Mengjie Chen,^a Chusen Huang,^a Chunsheng He,^a Weiping Zhu,*^a Yufang Xu^a and Yunfeng Lu*^b

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Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China
E-mail: wpzhu@ecust.edu.cn ;
Fax: +86 21-64252603

Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, USA
E-mail: luucla@ucla.edu

Chem. Commun., 2012,48, 9522-9524

DOI: 10.1039/C2CC34290A
Received 15 Jun 2012, Accepted 07 Aug 2012
First published online 08 Aug 2012

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A glucose-responsive controlled-release system based on the competitive combination between glucose oxidase, glucosamine and glucose has been described, which exhibits perfect controlled release properties and high selectivity for glucose over other monosaccharides. This paved the way for a new generation of stimuli-responsive delivery systems.

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Mengjie Chen
Chusen Huang
Chunsheng He
Weiping Zhu
Yufang Xu
Yunfeng Lu

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