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Issue 75, 2012
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Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction.

Graphical abstract: Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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Publication details

The article was received on 11 Jun 2012, accepted on 23 Jul 2012 and first published on 24 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC34185A
Citation: Chem. Commun., 2012,48, 9376-9378
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    Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

    S. Kawamura, T. Kawabata, K. Ishizuka and M. Nakamura, Chem. Commun., 2012, 48, 9376
    DOI: 10.1039/C2CC34185A

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