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Issue 78, 2012
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Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry

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Abstract

ortho- and para-Phenylenediamines were desymmetrised and quantitatively transformed into mono- and bis-(thio)ureas or mixed thioureaureas through a one-pot mechanochemical click reaction sequence; mechanochemical desymmetrisation proceeds quantitatively without excess reagents and allows the controlled extension of a molecular structure by combining normally competing reactions.

Graphical abstract: Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry

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Publication details

The article was received on 05 Jun 2012, accepted on 13 Aug 2012 and first published on 13 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC34013E
Citation: Chem. Commun., 2012,48, 9705-9707
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    Desymmetrisation of aromatic diamines and synthesis of non-symmetrical thiourea derivatives by click-mechanochemistry

    V. Štrukil, D. Margetić, M. D. Igrc, M. Eckert-Maksić and T. Friščić, Chem. Commun., 2012, 48, 9705
    DOI: 10.1039/C2CC34013E

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