Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

Xiao Mei; Shun Yang; Dongyun Chen; Najun Li; Hua Li; Qingfeng Xu; Jianfeng Ge; Jianmei Lu

doi:10.1039/C2CC33995A

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Chemical Communications

Issue 80, 2012

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Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

Xiao Mei,^a Shun Yang,^a Dongyun Chen,^a Najun Li,*^a Hua Li,^a Qingfeng Xu,^a Jianfeng Ge^a and Jianmei Lu*^a

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Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, P. R. China
E-mail: lujm@suda.edu.cn ;
Fax: +86 512 6588 0367 ;
Tel: +86 512 6588 0368

Chem. Commun., 2012,48, 10010-10012

DOI: 10.1039/C2CC33995A
Received 04 Jun 2012, Accepted 21 Aug 2012
First published online 22 Aug 2012

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Hollow mesoporous silica nanoparticles (HMSs) were modified by β-cyclodextrin via a “click” reaction, an amphiphilic copolymer with a trans-azobenzene structure was then assembled onto β-cyclodextrin to cover the surface of the HMSs. The prepared nanocomposites can release drugs in a “release-stop-release” manner by converting light irradiation.

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Xiao Mei
Shun Yang
Dongyun Chen
Najun Li
Hua Li
Qingfeng Xu
Jianfeng Ge
Jianmei Lu

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Chemical Communications

Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

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Light-triggered reversible assemblies of azobenzene-containing amphiphilic copolymer with β-cyclodextrin-modified hollow mesoporous silica nanoparticles for controlled drug release

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