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Issue 74, 2012
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Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

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Abstract

A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.

Graphical abstract: Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

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Publication details

The article was received on 15 May 2012, accepted on 30 Jul 2012 and first published on 30 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33511E
Citation: Chem. Commun., 2012,48, 9310-9312
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    Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system

    S. D'Errico, G. Oliviero, J. Amato, N. Borbone, V. Cerullo, A. Hemminki, V. Piccialli, S. Zaccaria, L. Mayol and G. Piccialli, Chem. Commun., 2012, 48, 9310
    DOI: 10.1039/C2CC33511E

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