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Issue 66, 2012
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The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

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Abstract

An unprecedented direct reductive amination of electron-deficient amines such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, Ar2PO-, etc. protected amines with aldehydes is achieved using the Re2O7 catalyst and silanes as the hydride source. Excellent regioselective mono-alkylation and chemoselective reductive-amination were observed.

Graphical abstract: The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

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Publication details

The article was received on 03 May 2012, accepted on 02 Jul 2012 and first published on 02 Jul 2012


Article type: Communication
DOI: 10.1039/C2CC33185C
Citation: Chem. Commun., 2012,48, 8276-8278
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    The direct reductive amination of electron-deficient amines with aldehydes: the unique reactivity of the Re2O7 catalyst

    B. G. Das and P. Ghorai, Chem. Commun., 2012, 48, 8276
    DOI: 10.1039/C2CC33185C

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