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Issue 51, 2012
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Microwave accelerated Glaser–Hay macrocyclizations at high concentrations

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Abstract

Efficient macrocyclization can be conducted at high concentrations employing microwave irradiation and a phase separation strategy. The rate of the Glaser–Hay macrocyclization is accelerated using microwave irradiation and reaction times decreased from 48 h to 1–6 h, depending on the nature of the substrate. Macrocyclization concentrations could be increased up to 0.1 M compared to traditional concentrations (0.2 mM).

Graphical abstract: Microwave accelerated Glaser–Hay macrocyclizations at high concentrations

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Publication details

The article was received on 05 Apr 2012, accepted on 03 May 2012 and first published on 04 May 2012


Article type: Communication
DOI: 10.1039/C2CC32464D
Citation: Chem. Commun., 2012,48, 6420-6422
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    Microwave accelerated Glaser–Hay macrocyclizations at high concentrations

    A. Bédard and S. K. Collins, Chem. Commun., 2012, 48, 6420
    DOI: 10.1039/C2CC32464D

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