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Issue 50, 2012
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A robust, high-sensitivity stealth probe for peptidases

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Abstract

A robust, modular fluorogenic probe system has been developed which allows the highly sensitive off–ON detection of aminopeptidase activity by releasing an exceptionally photostable, insoluble, phenolic ESIPT fluorophore. The probes generate no false positive signal in over 24 hours, but when activated give a signal within 10 minutes.

Graphical abstract: A robust, high-sensitivity stealth probe for peptidases

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Publication details

The article was received on 27 Mar 2012, accepted on 01 May 2012 and first published on 02 May 2012


Article type: Communication
DOI: 10.1039/C2CC32227G
Citation: Chem. Commun., 2012,48, 6253-6255
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    A robust, high-sensitivity stealth probe for peptidases

    O. Thorn-Seshold, M. Vargas-Sanchez, S. McKeon and J. Hasserodt, Chem. Commun., 2012, 48, 6253
    DOI: 10.1039/C2CC32227G

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