Issue 47, 2012
From the journal:

Chemical Communications

The conformational locking of asparagine†

Carlos Cabezas,a   Marcelino Varela,a   Isabel Peña,a   Santiago Mata,a   Juan C. Lópeza  and  José L. Alonso*a  

* Corresponding authors

a Grupo de Espectroscopía Molecular (GEM), Edificio Quifima, Área de Química-Física, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Científico UVa, Universidad de Valladolid, 47005 Valladolid, Spain
E-mail: jlalonso@qf.uva.es
Fax: +34 983186349
Tel: +34 983186348

Abstract

One dominant structure has been identified analysing the rotational spectrum of asparagine in sharp contrast with the multiconformational behaviour for other amino acids with polar side chains. This locking of the conformational variety to a single conformer has been ascribed to an intramolecular hydrogen bonding network involving α-amine, α-carboxylic and amide groups.

Graphical abstract: The conformational locking of asparagine

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Article information

DOI
https://doi.org/10.1039/C2CC32109B
Article type
Communication
Submitted
22 Mar 2012
Accepted
23 Apr 2012
First published
24 Apr 2012

Chem. Commun., 2012,48, 5934-5936

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The conformational locking of asparagine

C. Cabezas, M. Varela, I. Peña, S. Mata, J. C. López and J. L. Alonso, Chem. Commun., 2012, 48, 5934 DOI: 10.1039/C2CC32109B

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