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Issue 40, 2012
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CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

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Abstract

A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH4HCO3 gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO2 gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.

Graphical abstract: CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

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Publication details

The article was received on 07 Mar 2012, accepted on 20 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31697H
Citation: Chem. Commun., 2012,48, 4869-4871
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    CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

    J. Liu, H. Ma, T. Wei and X. Liang, Chem. Commun., 2012, 48, 4869
    DOI: 10.1039/C2CC31697H

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