Issue 40, 2012

CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

Abstract

A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH4HCO3 gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO2 gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.

Graphical abstract: CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2012
Accepted
20 Mar 2012
First published
20 Mar 2012

Chem. Commun., 2012,48, 4869-4871

CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

J. Liu, H. Ma, T. Wei and X. Liang, Chem. Commun., 2012, 48, 4869 DOI: 10.1039/C2CC31697H

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