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Issue 40, 2012
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A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

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Abstract

Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.

Graphical abstract: A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

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Publication details

The article was received on 28 Feb 2012, accepted on 15 Mar 2012 and first published on 15 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31495A
Citation: Chem. Commun., 2012,48, 4893-4895
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    A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines

    P. R. Girling, A. S. Batsanov, H. C. Shen and A. Whiting, Chem. Commun., 2012, 48, 4893
    DOI: 10.1039/C2CC31495A

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