Methylation of the peptide bond in model azadipeptides leads to the E configuration and hence to atropisomerism due to a restricted rotation around the N–N axis.
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Induction of chirality: experimental evidence of atropisomerism in azapeptides
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a
Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
E-mail: guetschow@uni-bonn.de
E-mail: guetschow@uni-bonn.de
b
Institute of Inorganic Chemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany
Chem. Commun., 2012,48, 5772-5774
DOI: 10.1039/C2CC31161E
Received 16 Feb 2012, Accepted 17 Apr 2012
First published online 18 Apr 2012
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