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Issue 40, 2012
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A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines

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Abstract

A range of 3H-indoles and 2H-benzo[b][1,4]thiazines smoothly undergo asymmetric Strecker reaction with ethyl cyanoformate in the presence of a Cinchona alkaloid-based thiourea catalyst at 10 °C to give structurally diverse nitrogen-containing heterocycles in good to excellent yields and with excellent ee.

Graphical abstract: A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines

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Publication details

The article was received on 11 Feb 2012, accepted on 20 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31001E
Citation: Chem. Commun., 2012,48, 4899-4901
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    A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines

    Y. Shao and S. Tian, Chem. Commun., 2012, 48, 4899
    DOI: 10.1039/C2CC31001E

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