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Issue 42, 2012
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Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(I) complexes of SpinPhox ligands

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Abstract

The Ir(I) complexes of chiral spiro phosphino–oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides with up to 97% ee.

Graphical abstract: Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(i) complexes of SpinPhox ligands

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Publication details

The article was received on 04 Feb 2012, accepted on 02 Apr 2012 and first published on 03 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC30812F
Citation: Chem. Commun., 2012,48, 5172-5174
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    Highly enantioselective asymmetric hydrogenation of (E)-β,β-disubstituted α,β-unsaturated Weinreb amides catalyzed by Ir(I) complexes of SpinPhox ligands

    J. Shang, Z. Han, Y. Li, Z. Wang and K. Ding, Chem. Commun., 2012, 48, 5172
    DOI: 10.1039/C2CC30812F

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