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State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, P.R. China
; Fax: +86 21 64166128
Chem. Commun., 2012,48, 5172-5174
04 Feb 2012,
02 Apr 2012
First published online
03 Apr 2012
The Ir(I) complexes of chiral spiro phosphino–oxazoline ligands (SpinPhox) have demonstrated good to excellent enantioselectivity in the asymmetric hydrogenation (AH) of a variety of (E)-β,β-disubstituted α,β-unsaturated N-methoxy-N-methylamides, affording the corresponding optically active Weinreb amides with up to 97% ee.