Poly(3-hydroxyalkanoate)-derived amphiphilic graft copolymers for the design of polymersomes

Julien Babinot; Jean-Michel Guigner; Estelle Renard; Valérie Langlois

doi:10.1039/C2CC30482A

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Chemical Communications

Issue 43, 2012

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Poly(3-hydroxyalkanoate)-derived amphiphilic graft copolymers for the design of polymersomes

Julien Babinot,^a Jean-Michel Guigner,^b Estelle Renard^a and Valérie Langlois*^a

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Institut de Chimie et des Matériaux Paris-Est (ICMPE), Systèmes Polymères Complexes, UMR CNRS 7182, 2-8 rue Henri Dunant, 94320 Thiais, France
E-mail: langlois@icmpe.cnrs.fr ;
Fax: +33 1 49 78 12 08 ;
Tel: +33 1 49 78 12 17

Institut de Minéralogie et de Physique des Milieux Condensés (IMPMC), 4 place Jussieu, 75005 Paris, France

Chem. Commun., 2012,48, 5364-5366

DOI: 10.1039/C2CC30482A
Received 20 Jan 2012, Accepted 04 Apr 2012
First published online 04 Apr 2012

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Amphiphilic graft copolymers composed of biocompatible bacterial poly(3-hydroxyalkanoate) and poly(ethylene glycol) have been synthesized by thiol–ene addition. They were demonstrated to form well-defined nanoscale vesicles in water by cryo-transmission electron microscopy.

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