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Issue 41, 2012
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Isonicotinamide self-association: the link between solvent and polymorph nucleation

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Abstract

We show that, in a controlled and reproducible way, specific solvents lead to specific polymorphic forms of isonicotinamide. We argue on the basis of Raman and FTIR spectroscopy that the hydrogen bonding in solution kinetically drives the nucleation towards a specific form. This generally may lead to good understanding and control of polymorphism and crystal nucleation.

Graphical abstract: Isonicotinamide self-association: the link between solvent and polymorph nucleation

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Publication details

The article was received on 22 Dec 2011, accepted on 22 Mar 2012 and first published on 23 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC18025A
Citation: Chem. Commun., 2012,48, 4983-4985
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    Isonicotinamide self-association: the link between solvent and polymorph nucleation

    S. A. Kulkarni, E. S. McGarrity, H. Meekes and J. H. ter Horst, Chem. Commun., 2012, 48, 4983
    DOI: 10.1039/C2CC18025A

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