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Issue 43, 2012
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Efficient γ-amino-proline-derived cell penetrating peptide–superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

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Abstract

Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT–SPION conjugate.

Graphical abstract: Efficient γ-amino-proline-derived cell penetrating peptide–superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

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Publication details

The article was received on 19 Dec 2011, accepted on 03 Apr 2012 and first published on 04 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC17937G
Citation: Chem. Commun., 2012,48, 5322-5324
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    Efficient γ-amino-proline-derived cell penetrating peptide–superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents

    S. Cavalli, D. Carbajo, M. Acosta, S. Lope-Piedrafita, A. P. Candiota, C. Arús, M. Royo and F. Albericio, Chem. Commun., 2012, 48, 5322
    DOI: 10.1039/C2CC17937G

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