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Issue 7, 2012
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Copper-free click—a promising tool for pre-targeted PET imaging

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Abstract

The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [18F]2-fluoroethylazide ([1818F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.

Graphical abstract: Copper-free click—a promising tool for pre-targeted PET imaging

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Publication details

The article was received on 06 Oct 2011, accepted on 17 Nov 2011 and first published on 18 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16220A
Citation: Chem. Commun., 2012,48, 991-993
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    Copper-free click—a promising tool for pre-targeted PET imaging

    H. L. Evans, R. L. Slade, L. Carroll, G. Smith, Q. Nguyen, L. Iddon, N. Kamaly, H. Stöckmann, F. J. Leeper, E. O. Aboagye and A. C. Spivey, Chem. Commun., 2012, 48, 991
    DOI: 10.1039/C1CC16220A

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