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Issue 6, 2012
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Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

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Abstract

We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.

Graphical abstract: Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

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Publication details

The article was received on 05 Oct 2011, accepted on 15 Nov 2011 and first published on 15 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC16178D
Citation: Chem. Commun., 2012,48, 835-837
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    Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

    P. Yang, M. Wang, C. Y. He and S. Q. Yao, Chem. Commun., 2012, 48, 835
    DOI: 10.1039/C1CC16178D

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