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Issue 6, 2012
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Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation

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Abstract

The KRAS transcript is characterized by a 192-nt 5′-UTR containing repetitive runs of two-guanines which can fold in several G-quadruplexes. These folded structures have a high affinity for the cationic porphyrin tri-meso(N-methyl-4-pyridyl), meso(N-tetradecyl-4-pyridyl) porphine (TMPyP4-C14), which efficiently penetrates cell membranes. Upon photoactivation TMPyP4-C14 induces a dramatic down-regulation of oncogenic KRAS and cell growth arrest in pancreatic cancer cells.

Graphical abstract: Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation

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Publication details

The article was received on 21 Sep 2011, accepted on 08 Nov 2011 and first published on 29 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15850C
Citation: Chem. Commun., 2012,48, 874-876
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    Photoactivated cationic alkyl-substituted porphyrin binding to g4-RNA in the 5′-UTR of KRAS oncogene represses translation

    M. Faudale, S. Cogoi and L. E. Xodo, Chem. Commun., 2012, 48, 874
    DOI: 10.1039/C1CC15850C

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