Jump to main content
Jump to site search

Issue 6, 2012
Previous Article Next Article

The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

Author affiliations

Abstract

The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABAC-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABAC.

Graphical abstract: The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Sep 2011, accepted on 17 Nov 2011 and first published on 05 Dec 2011


Article type: Communication
DOI: 10.1039/C1CC15816C
Citation: Chem. Commun., 2012,48, 829-831
  •   Request permissions

    The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor

    I. Yamamoto, M. J. T. Jordan, N. Gavande, M. R. Doddareddy, M. Chebib and L. Hunter, Chem. Commun., 2012, 48, 829
    DOI: 10.1039/C1CC15816C

Search articles by author

Spotlight

Advertisements