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Issue 4, 2012
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Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

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Abstract

We have combined an allosteric molecular beacon for target recognition and guanine-rich DNAzyme for signal amplification to develop a new platform for visual detection of nucleic acids with single-base mismatch detection capability. The fully DNA-structured platform can undergo color change in response to target DNA/RNA, which enables sensitive and selective visual detection in biological samples.

Graphical abstract: Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

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Publication details

The article was received on 18 Sep 2011, accepted on 19 Oct 2011 and first published on 07 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15777A
Citation: Chem. Commun., 2012,48, 576-578
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    Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability

    Y. Song, W. Zhang, Y. An, L. Cui, C. Yu, Z. Zhu and C. J. Yang, Chem. Commun., 2012, 48, 576
    DOI: 10.1039/C1CC15777A

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