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Issue 11, 2012
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Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

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Abstract

Single molecule recognition imaging and dynamic force spectroscopy (DFS) analysis showed strong binding affinity between an aptamer and ricin, which was comparable with antibody–ricin interaction. Molecular simulation showed a ricin binding conformation with aptamers and gave different ricin conformations immobilizing on substrates that were consistent with AFM images.

Graphical abstract: Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

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Publication details

The article was received on 12 Sep 2011, accepted on 30 Oct 2011 and first published on 11 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15644F
Citation: Chem. Commun., 2012,48, 1644-1646
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    Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

    B. Wang, C. Guo, G. Chen, B. Park and B. Xu, Chem. Commun., 2012, 48, 1644
    DOI: 10.1039/C1CC15644F

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