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Issue 13, 2012
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Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

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Abstract

A metal complex is identified in which the metal fulfills two independent functions: as a structural scaffold for the specific molecular recognition of protein kinases resulting in antiangiogenic properties, together with a visible-light-induced photoreactivity triggering apopotosis in cancer cells.

Graphical abstract: Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

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Publication details

The article was received on 29 Aug 2011, accepted on 19 Oct 2011 and first published on 07 Nov 2011


Article type: Communication
DOI: 10.1039/C1CC15378A
Citation: Chem. Commun., 2012,48, 1863-1865
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    Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

    A. Kastl, A. Wilbuer, A. L. Merkel, L. Feng, P. Di Fazio, M. Ocker and E. Meggers, Chem. Commun., 2012, 48, 1863
    DOI: 10.1039/C1CC15378A

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