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Issue 10, 2012
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Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

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Abstract

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.

Graphical abstract: Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

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Publication details

The article was received on 01 Aug 2011, accepted on 12 Sep 2011 and first published on 28 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC14730G
Citation: Chem. Commun., 2012,48, 1416-1418
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    Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

    A. B. Mahon and P. S. Arora, Chem. Commun., 2012, 48, 1416
    DOI: 10.1039/C1CC14730G

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