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Issue 17, 2012
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A water soluble Al3+ selective colorimetric and fluorescent turn-on chemosensor and its application in living cell imaging

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Abstract

An efficient water soluble fluorescent Al3+ receptor, 1-[[(2-furanylmethyl)imino]methyl]-2-naphthol (1-H) was synthesized and characterized by physico-chemical and spectroscopic tools along with single crystal X-ray crystallography. High selectivity and affinity of 1-H towards Al3+ in HEPES buffer (DMSO/water: 1/100) of pH 7.4 at 25 °C showed it to be suitable for detection of intracellular Al3+ by fluorescence microscopy. Metal ions, viz. alkali (Na+, K+), alkaline earth (Mg2+, Ca2+), and transition-metal ions (Ni2+, Zn2+, Cd2+, Co2+, Cu2+, Fe3+, Cr3+/6+, Hg2+) and Pb2+, Ag+ did not interfere. The lowest detection limit for Al3+ was calculated to be 6.03 × 10−7 M in 100 mM HEPES buffer (DMSO/water: 1/100). Theoretical calculations have also been included in support of the configuration of the probe–aluminium complex.

Graphical abstract: A water soluble Al3+ selective colorimetric and fluorescent turn-on chemosensor and its application in living cell imaging

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Publication details

The article was received on 28 Apr 2012, accepted on 08 Jun 2012 and first published on 08 Jun 2012


Article type: Paper
DOI: 10.1039/C2AN35560D
Citation: Analyst, 2012,137, 3975-3981
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    A water soluble Al3+ selective colorimetric and fluorescent turn-on chemosensor and its application in living cell imaging

    S. Sen, T. Mukherjee, B. Chattopadhyay, A. Moirangthem, A. Basu, J. Marek and P. Chattopadhyay, Analyst, 2012, 137, 3975
    DOI: 10.1039/C2AN35560D

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