Jump to main content
Jump to site search

Issue 8, 2012
Previous Article Next Article

Fabrication of large-area ordered and reproducible nanostructures for SERS biosensor application

Author affiliations

Abstract

We propose a large-area SERS device with efficient fluorescence quenching capability. The substrate is based on anodic porous alumina templates with various pore size and wall thickness as small as 15 and 36 nm, respectively. The nano-patterned SERS substrate, with excellent control and reproducibility of plasmon-polaritons generation, shows very efficient enhanced Raman signal in the presence of intrinsically fluorescent molecules such as cresyl violet, rhodamine, and green fluorescent protein. This work demonstrates that, when the nanostructures are properly designed and fabricated, Raman and fluorescence spectroscopy can be used in combination in order to obtain complementary molecular informations. Theoretical simulation shows excellent agreement with the experimental findings. The enhancement factor is found to be 103–104, with respect to flat gold surface when the molecules are supposed to be closely packed, with considerable fluorescence suppression, showing a promising disposable biosensor.

Graphical abstract: Fabrication of large-area ordered and reproducible nanostructures for SERS biosensor application

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Oct 2011, accepted on 13 Jan 2012 and first published on 22 Feb 2012


Article type: Paper
DOI: 10.1039/C2AN16022F
Citation: Analyst, 2012,137, 1785-1792
  •   Request permissions

    Fabrication of large-area ordered and reproducible nanostructures for SERS biosensor application

    G. Das, N. Patra, A. Gopalakrishnan, R. P. Zaccaria, A. Toma, S. Thorat, E. Di Fabrizio, A. Diaspro and M. Salerno, Analyst, 2012, 137, 1785
    DOI: 10.1039/C2AN16022F

Search articles by author

Spotlight

Advertisements