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Issue 16, 2012
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Simple, sensitive and selective detection of dopamine using dithiobis(succinimidylpropionate)-modified gold nanoparticles as colorimetric probes

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Abstract

In this paper, we report a simple, sensitive and selective colorimetric visualization of dopamine (DA) using dithiobis(succinimidylpropionate) (DSP)-modified gold nanoparticles (AuNPs) as probes and ferric ions as cross-linkers. Via the standard amine coupling reaction between the amino groups of DA and activated carboxyl groups of DSP, DA molecules can be assembled onto the surface of DSP-AuNPs. Accordingly, Fe3+ ions induce a change of DSP-AuNPs in color and UV-vis absorbance by coordinating to the catechol groups of the anchored DA. The pH dependence and mechanism of this method are discussed. A detection limit of 2 nM was obtained, which is lower than those achievable with currently used chromatographic and electrochemical techniques. The feasibility for the detection of DA in artificial cerebrospinal fluid has been demonstrated.

Graphical abstract: Simple, sensitive and selective detection of dopamine using dithiobis(succinimidylpropionate)-modified gold nanoparticles as colorimetric probes

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Publication details

The article was received on 21 Feb 2012, accepted on 18 Jun 2012 and first published on 18 Jun 2012


Article type: Paper
DOI: 10.1039/C2AN35734H
Citation: Analyst, 2012,137, 3794-3799
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    Simple, sensitive and selective detection of dopamine using dithiobis(succinimidylpropionate)-modified gold nanoparticles as colorimetric probes

    L. Liu, S. Li, L. Liu, D. Deng and N. Xia, Analyst, 2012, 137, 3794
    DOI: 10.1039/C2AN35734H

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